Dosage Forms & Strengths
Hypertension
Oral
- Initial: 2.5-5 mg PO qDay
- Maintenance: 10-40 mg/day PO qDay or divided q12hr
IV
- 1.25 mg/dose IV over 5 minutes q6hr; doses up to 5 mg/dose IV q6hr have been administered
Left Ventricular Dysfunction
Initial: 2.5 mg PO q12hr
May titrate up to 20 mg/day
Congestive Heart Failure
Initial: 2.5 mg PO qDay or q12hr
Maintenance: 5-40 mg/Day PO divided q12hr; titrate slowly q2Weeks
IV: 1.25-5 mg q6hr; avoid IV administration in unstable heart failure or acute myocardial infarction
Dosing Modifications
Hepatic impairment: No dosage adjustment required
Renal impairment
- CrCl <30 mL/min: (PO) Initiate 2.5 mg; titrate to response; not to exceed 40 mg
- Dialysis: 2.5 mg PO on day of dialysis; adjust dose on nondialysis days according to BP
- CrCl <30 mL/min: (IV) Initiate 0.625 mg q6hr; titrate based on response
- CrCl ≥30 mL/min: (PO) Initiate 5 mg/day; titrate to maximum of 40 mg
- CrCl ≥30 mL/min: (IV) 1.25 mg q6hr; titrate based on response
Dosing Considerations
Beneficial for many patients at risk for heart disease
Reduces risk of MI, stroke, diabetic nephropathy, microalbuminuria, new-onset DM
Consider starting an ACE inhibitor in high-risk patients, even if no HTN or CHF
May prolong survival in CHF
May preserve renal function in DM
May help to prevent migraine headache
Good choice in hyperlipidemia patients
Requires weeks for full effect; to start, use low dose and titrate q1-2Weeks
Abrupt discontinuation not associated with rapid increase in BP
Interactions
Interaction Checker
enalapril and
Sort by :
Contraindicated (2)
- aliskiren
- protein a column
Serious - Use Alternative (12)
- allopurinol
- azilsartan
- candesartan
- eprosartan
- irbesartan
- losartan
- olmesartan
- potassium phosphates, iv
- pregabalin
- sacubitril/valsartan
- telmisartan
- valsartan
Significant - Monitor Closely (109)
- albiglutide
- aldesleukin
- alfuzosin
- aluminum hydroxide
- amifostine
- amiloride
- amphetamine
- asenapine
- aspirin
- aspirin/citric acid/sodium bicarbonate
- avanafil
- azathioprine
- bumetanide
- calcium carbonate
- canagliflozin
- carbamazepine
- carbidopa
- celecoxib
- chlorpropamide
- choline magnesium trisalicylate
- cyclosporine
- daclatasvir
- dalteparin
- diclofenac
- diflunisal
- digoxin
- doxazosin
- drospirenone
- enoxaparin
- eplerenone
- ethacrynic acid
- etodolac
- everolimus
- exenatide injectable solution
- exenatide injectable suspension
- fenoprofen
- ferrous gluconate
- flurbiprofen
- furosemide
- glimepiride
- glipizide
- gliquidone
- glyburide
- gold sodium thiomalate
- heparin
- ibuprofen
- icatibant
- indomethacin
- insulin aspart
- insulin degludec
- insulin degludec/insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhaled
- insulin lispro
- insulin nph
- insulin regular human
- itraconazole
- ketoconazole
- ketoprofen
- ketorolac
- ketorolac intranasal
- lanthanum carbonate
- levodopa
- liraglutide
- lithium
- lurasidone
- maraviroc
- mefenamic acid
- meloxicam
- mipomersen
- moxisylyte
- nabumetone
- naproxen
- nesiritide
- nitroglycerin rectal
- ombitasvir/paritaprevir/ritonavir
- oxaprozin
- phenoxybenzamine
- phentolamine
- piroxicam
- potassium acid phosphate
- potassium chloride
- potassium citrate
- potassium citrate/citric acid
- prazosin
- rose hips
- salsalate
- silodosin
- sirolimus
- sodium bicarbonate
- sodium citrate/citric acid
- sofosbuvir/velpatasvir
- spironolactone
- sulfasalazine
- sulindac
- tadalafil
- temsirolimus
- terazosin
- tinzaparin
- tolazamide
- tolbutamide
- tolmetin
- torsemide
- triamterene
- trimethoprim
- xipamide
- zotepine
Minor (32)
- aceclofenac
- acemetacin
- agrimony
- aspirin rectal
- brimonidine
- capsicum
- chlorpromazine
- cornsilk
- creatine
- cyclosporine
- etoricoxib
- fenbufen
- fluphenazine
- lofexidine
- lornoxicam
- maitake
- octacosanol
- parecoxib
- perphenazine
- probenecid
- prochlorperazine
- promazine
- promethazine
- reishi
- rifampin
- salicylates (non-asa)
- shepherd's purse
- thioridazine
- tizanidine
- tolfenamic acid
- treprostinil
- trifluoperazil
Adverse Effects
1-10%
Dizziness (4-8%)
Hypotension (0.9-6.7%)
Headache (2-5%)
Chest pain (2%)
Cough (1-2%)
Rash (1.5%)
Frequency Not Defined
Asthenia
Nausea
Vomiting
Hyperkalemia
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